Pharmaceutical Sciences (PHSC)

A clinically oriented course in pharmacology with emphasis on those drugs most commonly used in Dentistry. The clinical aspects, mechanisms, interactions and contraindications of drugs taken by the dental patient are stressed.

Prerequisites: Permission of the instructor May be repeated; maximum credit 2 hours. The course will provide training in the comprehensive and presentation of cutting-edge primary literature in the field of social & administrative pharmaceutical sciences, which include, but are not limited to applications in/of sociology, psychology, management, marketing, economics, finances, epidemiology, and public health: and at the same time in developing scientific literature evaluation and general writing skills.

Prerequisites: Permission of the instructor This course integrates basic information on the chemotherapy of infectious diseases with a special emphasis on resistance to antimicrobial chemotherapy and development of new antimicrobial agents.

Prerequisites: Permission from course coordinator The students will learn the basic technologies associated with pharmaceutical research. The course is designed to introduce fundamentals of working in a pharmaceutical, drug development and delivery research environment. The laboratory component is included in order to provide demonstration of the underlying principles associated with common techniques/equipment used in such research.

Recent developments in the synthesis, structure, and function of biologically active peptides and their relationship to the treatment of disease in man.

Prerequisites: None The purpose of this course is to provide an expanded understanding of immunopharmacology, beyond that presented in a basic immunology course, to include an understanding of the mechanistic and research basis of the science. Basic principles of pharmacology, and the development and use of immunotherapeutics will also be emphasized.

Prerequisites: PHSC 5561 General Principles of Pharmacology. Introduce topics on drug metabolism and transporters that are important for drug disposition, drug-drug interaction (DDIs) and toxicities; describe contemporary methodologies in studying drug metabolism and transporters; provide hands-on training of Simcyp Simulator software to predict drug disposition and DDIs in humans. (SP I, II, & III)

Principles of radioactive tracer methodology used in health research. Basic radiation physics, radionuclide calculations, interactions of radiation with matter, methods of radiation detection and determination experimental design, radiological safety and application of radionuclides to research. Laboratory included.

Prerequisites: None Cross Listed: PHAR 7334 Introduction to the field of Nuclear Pharmacy. Topics include radiopharmaceutical quality control, stability and labeling techniques. Laboratory included.

Prerequisites: Permission of the instructor Introduction to psychosocial theories of patient and health provider behavior, evaluation of literature in which these theories are tested, and development of proposals to conduct theory-based research. Social and behavioral aspects of patient and health provider roles and relationships as they relate to medication use are emphasized.

The clinical toxicology of common agents ingested in overdoses. The practical management including stabilization of the patient, drug evacuation, drug elimination and prevention of organ damage. The evaluation of poison information literature and how to answer a poison related question.

Prerequisites: BMSC 6052 Cellular Systems II Course will discuss the role of drug disposition (uptake, distribution, metabolism and elimination) on pharmacokinetics and efficacy. Principles and utility of inverse agonism, biased agonism and paradoxical pharmacology, methods of receptor quantification (in vivo and in vitro), effect of chronic drug treatment and immunosuppressant pharmacology also will be addressed.

Prerequisites: Permission of Course Coordinator Coverage of basic principles of drug action, including in depth assessments of mechanism of action of drugs that influence the central and peripheral nervous systems, cardiovascular/renal system, endocrine system and immune system.

Prerequisites: PHSC 5561 Principles of General Pharmacology: The ins and outs of drug action. Course will address the biochemical, molecular and physiological mechanisms of drugs affecting the central nervous system, potential new drug targets for each condition, and methods for assessing the effectiveness of potential therapeutic agents.

Prerequisites: Permission of course coordinator; College of Pharmacy residents, fellows, or graduate students only. This course will provide students with the knowledge and skills to develop rational pharmacotherapy for pediatric patients. Instruction will primarily involve case-based learning, with an emphasis on evaluation of pertinent literature.

Prerequisites: PHSC 5561 Principles of General Pharmacology: The ins and outs of drug action. General principles of toxicology and systemic sites of action of toxicants, to include an understanding of the mechanistic and research basis of the science.

Prerequisites: PHSC 5561 General principles of Pharmacology; PHYO 6410 Genes to physiology: integrated cardiovascular and renal systems. Coverage of the mechanism of action of drugs that modulate cardiovascular, renal and endocrine systems, as well as methods and relevant model systems in which these methods can be employed to answer basic science questions and screen for clinical efficacy.

Fundamental principles, mathematical models, and clinical applications of pharmacokinetics.

Prerequisites: PHSC 5643 Pharmacokinetics Introduction to advanced topics that add complexity in pharmacokinetic and pharmacodynamic (PK/PD) data interpretation and analysis; description and development of physiologically-based PK models and diverse empirical and mechanism-based PD models to appropriately describe PK/PD data; and scaling up findings from animals to humans.

Research procedures in pharmacy administration including definition of the problem, scaling and measurement methods, sample size determination, questionnaire development, and selection of experimental or quasi-experimental designs.

Principles of management in providing ambulatory pharmaceutical services with emphasis on the efficient management of a community pharmacy within the dynamics of the health care system.

Principles of cost effectiveness analysis (CEA) and cost benefit analysis (CBA) applied to the evaluation of pharmacy services and related health care programs.

Prerequisites: None This course introduces the use of numerical methods for the analysis of data and the development of computational models. Lectures provide both theoretical background and practical examples (using Matlab). Three major components are analysis of experimental data, implementation of dynamic models, and identification of model parameters. (Fall I, II, III, IV)

Prerequisites: Permission. May be repeated; maximum credit 24 hours. Research Master's Thesis.

Prerequisites: Permission of instructor. May be repeated with a change of subject matter, maximum credit 12 hours. This course provides laboratory and library work to give qualified students an opportunity to pursue an original investigation or an interest in a special problem.

Prerequisites: Permission of the instructor May be repeated; maximum credit 6 hours. This course provides the opportunity for students to learn and experience an in-depth knowledge and appreciation for scientific skills and emphasizes techniques, instrumentation, and experimental design in a specific discipline within a multidisciplinary research environment.

Prerequisites: Permission of the instructor Cross Listed: OCNS 6002/GENC 6002 This course will prepare the graduate students to understand the influence of genetic variations among individuals and their contribution to differences in drug response. The students will learn basic principles of genetics and pharmacology and how genetic, environmental, lifestyle and nutritional factors affect drug response.

Prerequisites: PHSC 5563, General Pharmacology or an equivalent course This course provides instruction in drug transport and elimination, drug-receptor interactions, cancer chemotherapy, and immunopharmacology that are not addressed in introductory pharmacology courses.

General principles of toxicology and systemic sites of action of toxicants.

Prerequisites: Permission of the instructor May be repeated; maximum credit 10 hours. This course provides advanced instruction in topics that were introduced in existing courses, or it may be used to teach emerging concepts that are not currently included in the curriculum. Topics for this course may be chosen from the basic pharmaceutical sciences, clinical sciences, or the social and administrative sciences.

Prerequisites: None May be repeated; maximum credit 2 hours. The objectives of this course are for students to be able to critically analyze and appraise publications, organize and prepare a coherent presentation, and prepare a written critique of a selected article. This will help students interpret the relevance of findings in biological context and understand ethical responsibilities required for the scientific pursuit.

Advanced theoretical applications of physical and chemical principles to pharmaceutical systems.

Prerequisites: Graduate standing. Overview of research and educational methods for graduate students in the pharmaceutical sciences. This course will cover hypothesis development, grant writing, the patent process, course development, course assessment and grading.

May be repeated with change in subject matter; maximum credit two hours. Discussion and reports on assigned readings relative to different divisions in pharmaceutical sciences. Subject areas are: Medicinal Chemistry, Pharmacognosy (natural products), Nuclear Pharmacy, Pharmacodynamics/Toxicology, Hospital/Clinical Pharmacy, Pharmaceutics, and Pharmacy Management.

May be repeated with change in subject matter; maximum credit four hours. A general seminar for all divisions of graduate study in pharmaceutical sciences.

May be repeated to a maximum of 45 semester hours. A maximum of 16 hours per semester is allowed.